I stumbled on this when trying to run the new version of STS (Eclipse) on my work computer, which currently does not have Administrative Rights, yet has Windows 10 “Smart Screen” set to prevent running “unrecognized” applications.

If you try to run an application and the Smart Screen is preventing it from running, right click on the application, click Sent to Compressed File (.zip), then Extract the file and run it. Because Windows Smart Screen sees that you created the .zip file, it will assume that you can trust the contents when you extract it. Replace the original file with this file, and you are off to the races.

YMMV, do not do this at home, or on a computer that you are trusted to protect, etc.